D-erythro-Sphingosine (synthetic)
Chemical Name: trans-D-erythro-2-Amino-4-octadecene-1,3-diol
Biological Activity
D-erythro-Sphingosine (synthetic) is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Sphingosine inhibition and promotion of histamine release from isolated rat mast cells.
Grossman
Agents Actions, 1990;31:171 -
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Merrill et al.
Biochemistry, 1989;28:3138
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