DCPIB

Tocris Bioscience | Catalog # 1540

Blocker of VRAC/ICl, swell
Tocris Bioscience

Key Product Details

Description

Blocker of VRAC/ICl, swell

Alternative Names

SN-401
View all Other Chloride Channel Blockers »

Product Description

DCPIB is a volume-regulated anion channel (VRAC) blocker (IC50 ~ 2 μM in rat pancreatic β-cells). Also blocks ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K+ channels and inhibits TRESK, TASK1 and TASK3 K+ channels at 10 μM, in vitro. Also inhibits VRAC-mediated 2'3'-cyclic-GMP-AMP (cGAMP) transport.

Product Specifications for DCPIB

Molecular Weight

427.37

Formula

C22H28Cl2O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid

CAS Number

82749-70-0

PubChem ID

10071166

InChI Key

KHKGTPJPBOQECW-UHFFFAOYSA-N

SMILES

CCCCC1(CC2=C(C1=O)C(Cl)=C(Cl)C(OCCCC(O)=O)=C2)C1CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 42.74 100

Preparing Stock Solutions for DCPIB

The following data is based on the product molecular weight 427.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.70 mL 23.40 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Product Documents for DCPIB

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DCPIB

For research use only

Customer Reviews for DCPIB (1)

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  • a VRACs blocker
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 02/02/2018
    DCPIB is a volume regulated anion channel. We used at 20-30microM in rat brain slice.

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