DETA NONOate

Key Product Details

Product Description

Nitric oxide donor. Activates an inward current in cultured rat cerebellar granules cells. Increases cGMP production in cultured vascular smooth muscle cells. Reduces contractility of cardiac muscle preparations in vitro.

Product Specifications for DETA NONOate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DETA NONOate

The following data is based on the product molecular weight 163.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.13 mL	30.64 mL	61.28 mL
5 mM	1.23 mL	6.13 mL	12.26 mL
10 mM	0.61 mL	3.06 mL	6.13 mL
50 mM	0.12 mL	0.61 mL	1.23 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Olson Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 1997 PMID: 9039111
• Wegener Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice. Br.J.Pharmacol. 2002 PMID: 12023944
• Thompson The NO donor DETA-NONOate reversibly activates an inward current in neurones and is not mediated by the released nitric oxide. Br.J.Pharmacol. 2009 PMID: 19785659

Product Documents for DETA NONOate