DHC-156

Key Product Details

Product Description

DHC-156 is a brachyury down modulator (DC₅₀ = 4.1 μM, D_Max > 99% at 10 μM). DHC-156 down modulates brachyury post-translationally, in a proteasome- and lysosome-independent manner. DHC-156 down modulation of brachyury results in an irreversible impairment of chordoma tumor cell growth.

Product Specifications for DHC-156

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DHC-156

The following data is based on the product molecular weight 492.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.15 mL	20.31 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chase Development of a small molecule downmodulator for the transcription factor brachyury. Angew.Chem.Int.Ed.Engl. 2024 PMID: 38348945

Product Documents for DHC-156