Diazoxide

Key Product Details

Product Description

Diazoxide is an antihypertensive, activates ATP-dependent K⁺ channels (K_ir6). Induces activation of PKCε, an intermediate in the opening of mitoK_ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Product Specifications for Diazoxide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Diazoxide

The following data is based on the product molecular weight 230.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.34 mL	21.68 mL	43.35 mL
5 mM	0.87 mL	4.34 mL	8.67 mL
10 mM	0.43 mL	2.17 mL	4.34 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

• Trube Opposite effects of tolbut. and Dox on the ATP-dependent K⁺ channel in mouse pancreatic β-cells. Pflugers Arch. 1986 PMID: 2431383
• Yamada and Rothman Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons. J.Physiol. 1992 PMID: 1302270
• Kim Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral K_ATP channel conferring cardioprotection against hypoxic injury. Br.J.Pharmacol. 2006 PMID: 17043673

Product Documents for Diazoxide