DIDS

Tocris Bioscience | Catalog # 4523

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor
Tocris Bioscience

Key Product Details

Description

Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor
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Product Description

DIDS is a ClC-Ka chloride channel blocker (IC50 = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC50 = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (KD = 2 μM).

Product Specifications for DIDS

Molecular Weight

498.48

Formula

C16H8N2Na2O6S4

Storage

Store at +4°C

Purity

≥95% (HPLC)

Chemical Name

4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt

CAS Number

67483-13-0

PubChem ID

5702690

InChI Key

GEPAYBXVXXBSKP-SEPHDYHBSA-L

SMILES

[Na+].[Na+].[O-]S(=O)(=O)C1=C(\C=C\C2=C(C=C(C=C2)N=C=S)S([O-])(=O)=O)C=CC(=C1)N=C=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Potassium bicarbonate (0.1M) 2.49 5

Preparing Stock Solutions for DIDS

The following data is based on the product molecular weight 498.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 40.12 mL 200.61 mL 401.22 mL
0.25 mM 8.02 mL 40.12 mL 80.24 mL
0.5 mM 4.01 mL 20.06 mL 40.12 mL
2.5 mM 0.80 mL 4.01 mL 8.02 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

Product Documents for DIDS

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DIDS

For research use only

Customer Reviews for DIDS (1)

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  • Blocks cellular swelling
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Verified Customer | Posted 02/06/2018
    Used at 250microM-500microM to block cellular swelling in the rat brain slice.

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