DIM

Tocris Bioscience | Catalog # 4502

Inhibits EGFR activation; also induces apoptosis
Tocris Bioscience
Discontinued Product
4502 has been discontinued. View all Cell Cycle Inhibitors products.

Key Product Details

Description

Inhibits EGFR activation; also induces apoptosis

Alternative Names

3,3-Diindolylmethane
View all Cell Cycle Inhibitors »

Product Description

DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines. Antiproliferative and inducer of apoptosis; promotes proteasomal degradation of Cdc25C and Cdk1. Inhibits phosphorylation of EGFR and downstream activation of ERK.

Product Specifications for DIM

Molecular Weight

246.31

Formula

C17H14N2

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

3,3'-Methylenediindole

CAS Number

1968-05-4

PubChem ID

10900930

InChI Key

SHXKYUYEFDONQC-UHFFFAOYSA-N

SMILES

C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.63 100
Ethanol 12.32 50

Preparing Stock Solutions for DIM

The following data is based on the product molecular weight 246.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.30 mL 40.60 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for DIM

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DIM

For research use only

Customer Reviews for DIM (1)

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  • Determination of DIM suppression of EGFR
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/14/2019
    To determine whether DIM suppressed the activation of EGFR by activating phosphorylation, cells were treated with epidermal growth factor.
    DIM 4502

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