Dimaprit dihydrochloride

Key Product Details

Product Description

Dimaprit dihydrochloride is a selective H₂ agonist with central effects upon systemic administration. Also inhibits nNOS (IC₅₀ = 49 μM).

Product Specifications for Dimaprit dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dimaprit dihydrochloride

The following data is based on the product molecular weight 234.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.35 mL	42.70 mL
5 mM	0.85 mL	4.27 mL	8.54 mL
10 mM	0.43 mL	2.14 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Parsons Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea)-a highly specific histamine H₂-receptor agonist. Part 1. Pharmacology. Agents Actions 1977 PMID: 871093
• Farzin and Attarzadeh Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 2000 PMID: 10980276
• Paquay Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br.J.Pharmacol. 1999 PMID: 10385230
• Durant Dimaprit-(S-[3-(N,N-dimethylamino)propyl]isothiourea) a highly specific histamine H₂-receptor agonist. Part 2. Structure activity considerations. Agents Actions 1977 PMID: 860674

Product Documents for Dimaprit dihydrochloride