DIO2 Antibody - BSA Free

Novus Biologicals | Catalog # NBP3-41877

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Format

BSA Free
View all DIO2 Primary Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Rat DIO2 (Uniprot#: P70551; Ser30-Phe259 (Uniprot#: P70551)

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for DIO2 Antibody - BSA Free

DIO2 Antibody

Western Blot: DIO2 Antibody [NBP3-41877] -

Western Blot: DIO2 Antibody [NBP3-41877] - Sample: Lane1: Rat Brain Tissue; Lane2: Mouse Brain Tissue.
DIO2 Antibody

Western Blot: DIO2 Antibody [NBP3-41877] -

Western Blot: DIO2 Antibody [NBP3-41877] - Sample: Recombinant DIO2, Rat.

Applications for DIO2 Antibody - BSA Free

Application
Recommended Usage

Western Blot

0.5-2ug/mL

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Format

BSA Free

Preservative

0.05% Proclin 300

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DIO2

DIO2 is encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Alternate Names

5DII, D2, deiodinase, iodothyronine, type II, DIOII, EC 1.97.1, EC 1.97.1.10, ITDI2, SelY, TXDI2thyroxine deiodinase, type II, Type 2 DI, type 2 iodothyronine deiodinase, type II iodothyronine deiodinase, type-II 5'deiodinase, Type-II 5'-deiodinase

Gene Symbol

DIO2

Additional DIO2 Products

Product Documents for DIO2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for DIO2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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