(±)-α-Lipoic acid

Key Product Details

Product Description

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

Product Specifications for (±)-α-Lipoic acid

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-α-Lipoic acid

The following data is based on the product molecular weight 206.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.85 mL	24.23 mL	48.47 mL
5 mM	0.97 mL	4.85 mL	9.69 mL
10 mM	0.48 mL	2.42 mL	4.85 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dong Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 2020 PMID: 32640500
• Shen Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 2011 PMID: 21108628
• Wheeler Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed
• Biewenga The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 1997 PMID: 9378235

Product Documents for (±)-α-Lipoic acid