(±)-Epibatidine

Key Product Details

Product Description

(±)-Epibatidine is a high affinity nicotinic agonist (K_i values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Licensing Information

Sold under license from the NIH, US Patent 5,314,899

Product Specifications for (±)-Epibatidine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-Epibatidine

The following data is based on the product molecular weight 208.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

15 14 13 12 11 6 5 4 3 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.79 mL	23.96 mL	47.92 mL
5 mM	0.96 mL	4.79 mL	9.58 mL
10 mM	0.48 mL	2.40 mL	4.79 mL
50 mM	0.10 mL	0.48 mL	0.96 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 58 publications citing the usage of this product.

• Spande Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc.
• Sharples UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 2000 PMID: 10751429
• Gerzarich Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 1995 PMID: 7476906
• Marks Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9536034
• Badio and Daly Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 1994 PMID: 8183234

Product Documents for (±)-Epibatidine