(±)-ML 209

Key Product Details

Product Description

(±)-ML 209 is a RORγt inverse agonist (IC₅₀ = 460 nM). Suppresses Th₁₇ cell differentiation and IL17A expression in vitro. Does not suppress transcription of RORα. Minimal activity displayed on ERα, LXRα and thyroid hormone receptors (IC₅₀ values >4.4 μM).

Product Specifications for (±)-ML 209

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-ML 209

The following data is based on the product molecular weight 441.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. Bioorg.Med.Chem. 2014 PMID: 24388993
• Huang DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature 2015 PMID: 26675721
• Kojetin REV-ERB and ROR nuclear receptors as drug targets. Nat.Rev.Drug Discov. 2014 PMID: 24577401
• Huang Identification of Potent and Selective RORγ Antagonists. Probe Reports from the NIH Molecular Libraries Program 2010 PMID:  23658948

Product Documents for (±)-ML 209