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DMB

Catalog #: 8874 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8874/50
8874/10

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DMB | CAS No. 281209-71-0 | Inflammasomes Activators
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Description: GSDMD (Gasdermin D) agonist, activator of pyroptosis, also GLP-1R agonist

Chemical Name: 6,7-Dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-2-quinoxalinamine

Purity: ≥98%

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Biological Activity

DMB is a Gasdermin D (GSDMD) agonist (EC50 = 0.7 mM). DMB directly bound to GSDMD (KD = 1.1 mM). DMB activates GSDMD pore formation and pyroptosis without cleaving GSDMD. In vivo, DMB suppresses tumor growth without harming GSDMD-expressing immune cells in mouse tumor models. DMB is also an agonist of glucagon-like peptide 1 receptor. DMB is orally bioavailable.

Technical Data

M.Wt:
348.25
Formula:
C13H15Cl2N3O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
281209-71-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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