DNQX

Tocris Bioscience | Catalog # 0189

Selective non-NMDA iGluR antagonist
Tocris Bioscience

Key Product Details

Description

Selective non-NMDA iGluR antagonist
View all AMPA Receptor Antagonists »

Product Description

DNQX is a selective non-NMDA receptor antagonist.

Water-soluble Salt also available.

Product Specifications for DNQX

Molecular Weight

252.14

Formula

C8H4N4O6

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

6,7-Dinitroquinoxaline-2,3-dione

CAS Number

2379-57-9

PubChem ID

3899541

InChI Key

RWVIMCIPOAXUDG-UHFFFAOYSA-N

SMILES

[O-][N+](=O)C1=C(C=C2NC(=O)C(=O)NC2=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.21 100

Preparing Stock Solutions for DNQX

The following data is based on the product molecular weight 252.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.97 mL 19.83 mL 39.66 mL
5 mM 0.79 mL 3.97 mL 7.93 mL
10 mM 0.40 mL 1.98 mL 3.97 mL
50 mM 0.08 mL 0.40 mL 0.79 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 865 publications citing the usage of this product.

Product Documents for DNQX

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DNQX

For research use only

Customer Reviews for DNQX (1)

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  • Block of AMPAR sIPSCs
    Name: Anonymous
    Species: Human
    Assay Type: Ex Vivo
    Cell Line/Tissue: Stem cell - derived neurons
    Verified Customer | Posted 10/15/2020
    DNQX was used to block spontaneous AMPA-receptor – generated excitatory post-synaptic currents (EPSCs) in stem-cell derived cultured dopamine neurons. 20 µM DNQX fully suppressed EPSC propagation, thus confirming the compound's specificity (see illustration). Preparation of 10 mM DMSO stock requires long sonication; in all other respects it is a perfect AMPA-receptor antagonist.
    DNQX 0189

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