Docetaxel

Tocris Bioscience | Catalog # 4056

Microtubule stabilizer
Tocris Bioscience

Key Product Details

Description

Microtubule stabilizer
View all Microtubule Binding Compounds »

Product Description

Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric tumors. Prevents microtubule depolymerization and disassembly in the absence of GTP. Exhibits cytotoxic activity.

Product Specifications for Docetaxel

Molecular Weight

807.88

Formula

C43H53NO14

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxy-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid

CAS Number

114977-28-5

PubChem ID

148124

InChI Key

ZDZOTLJHXYCWBA-VCVYQWHSSA-N

SMILES

O[C@@H]1C4=C(C)[C@@H](OC([C@H](O)[C@H]([C@]5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C[C@@](C(C)4C)(O)[C@@H](OC(C6=CC=CC=C6)=O)[C@@]([C@@]3(OC(C)=O)[C@H](OC3)C[C@@H]2O)([H])[C@]2(C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 80.79 100
Ethanol 80.79 100

Preparing Stock Solutions for Docetaxel

The following data is based on the product molecular weight 807.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.24 mL 6.19 mL 12.38 mL
5 mM 0.25 mL 1.24 mL 2.48 mL
10 mM 0.12 mL 0.62 mL 1.24 mL
50 mM 0.02 mL 0.12 mL 0.25 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

Product Documents for Docetaxel

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Docetaxel

For research use only

Related Research Areas

Microtubules

Customer Reviews for Docetaxel (2)

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  • Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human epidermal carcinoma cell line
    Verified Customer | Posted 11/17/2019
    Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
    Docetaxel 4056
  • Positive control for apoptosis
    Name: Anonymous
    Assay Type: In Vitro
    Verified Customer | Posted 12/01/2017
    Used as a control to induced apoptosis in cancer cell lines

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