DQP 1105

Tocris Bioscience | Catalog # 4491

GluN2C/GluN2D-selective NMDA antagonist
Tocris Bioscience

Key Product Details

Description

GluN2C/GluN2D-selective NMDA antagonist
View all NMDA Receptor Antagonists »

Product Description

DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Product Specifications for DQP 1105

Molecular Weight

558.42

Formula

C29H24BrN3O4

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid

CAS Number

380560-89-4

PubChem ID

2723792

InChI Key

JIQFFACVQXXHMY-YDALLXLXSA-N

SMILES

O=C2C(C4=NN(C(CCC(O)=O)=O)C(C5=CC=C(Br)C=C5)C4)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.84 100

Preparing Stock Solutions for DQP 1105

The following data is based on the product molecular weight 558.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.95 mL 17.91 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
10 mM 0.18 mL 0.90 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

Product Documents for DQP 1105

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DQP 1105

For research use only

Customer Reviews for DQP 1105

There are currently no reviews for this product. Be the first to review DQP 1105 and earn rewards!

Have you used DQP 1105?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card