DREADD agonist 21

Tocris Bioscience | Catalog # 5548

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Tocris Bioscience

Key Product Details

Description

Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

Alternative Names

Compound 21,C21
View all DREADD Activators »

Product Description

DREADD agonist 21 is a potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits > 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo. Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).

Product Specifications for DREADD agonist 21

Molecular Weight

278.35

Formula

C17H18N4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

CAS Number

56296-18-5

PubChem ID

11818276

InChI Key

JCBYXNSOLUVGTF-UHFFFAOYSA-N

SMILES

C1(N4CCNCC4)=NC(C=CC=C3)=C3NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.84 100
Ethanol 27.84 100

Preparing Stock Solutions for DREADD agonist 21

The following data is based on the product molecular weight 278.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.80 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for DREADD agonist 21

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DREADD agonist 21

For research use only

Citations for DREADD agonist 21

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  • Used in place of CNO
    Name: Anonymous
    Assay Type: In Vivo
    Cell Line/Tissue: Brain tissue
    Verified Customer | Posted 12/01/2017
    Used this product in place of CNO
    DREADD agonist 21 5548

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