DS2

Key Product Details

Product Description

DS2 is a positive allosteric modulator of GABA_A receptors. Potentiates GABA-evoked currents mediated by α4β3δ receptors (EC₅₀ = 142 nM, in vitro). Displays complex selectivity profile, with selectivity for δ-containing receptors (α4/6βxδ > α1βxδ >> γ2 > α4β3 GABA_A receptors). Enhances tonic currents of thalamocortical neurons in wild-type mice.

Product Specifications for DS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DS2

The following data is based on the product molecular weight 353.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.65 mL	28.26 mL	56.52 mL
2.5 mM	1.13 mL	5.65 mL	11.30 mL
5 mM	0.57 mL	2.83 mL	5.65 mL
25 mM	0.11 mL	0.57 mL	1.13 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

• Jensen A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA_A receptors. Br.J.Pharmacol. 2013 PMID: 23061935
• Ahring A pharmacological assessment of agonists and modulators at α4β2γ2 and α4β2δ GABA_A receptors: The challenge in comparing apples with oranges. Pharmacol.Res. 2016 PMID: 27178730
• Wafford Novel compounds selectively enhance δ subunit containing GABA_A receptors and increase tonic currents in thalamus. Neuropharmacology 2009 PMID: 18762200

Product Documents for DS2