dTRIM 24

Tocris Bioscience | Catalog # 6607

TRIM24 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

TRIM24 Degrader (PROTAC®)
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Product Description

dTRIM 24 is a Degrader (PROTAC®) composed of the TRIM24 ligand IACS-9571 conjugated to a VHL ligand. Displays dose- and time-dependent degradation of TRIM24 in cells, with maximum degradation achieved at 5 μM. Degradation phenotypically mirrors genetic deletion of TRIM24. Demonstrates antiproliferative effects in MOLM-13 cells. Cell permeable.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for dTRIM 24

Molecular Weight

1113.30

Formula

C55H68N8O13S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-15-(tert-Butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2170695-14-2

PubChem ID

131954388

InChI Key

QUQTXFIMYFMULC-OGOZKGDESA-N

SMILES

CCCOC1=CC=CC(OC2=C(C=C3N(C(N(C3=C2)C)=O)C)NS(=O)(C4=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)O)=O)=O)=O)=CC=C4)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.27 20
Ethanol 22.27 20

Preparing Stock Solutions for dTRIM 24

The following data is based on the product molecular weight 1113.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 4.49 mL 22.46 mL 44.91 mL
1 mM 0.90 mL 4.49 mL 8.98 mL
2 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.09 mL 0.45 mL 0.90 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for dTRIM 24

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for dTRIM 24

For research use only

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