DY 268

Key Product Details

Product Description

DY 268 is a potent FXR antagonist (IC₅₀ = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

Licensing Information

Sold under license from the Beckman Research Institute of the City of Hope.

Product Specifications for DY 268

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for DY 268

The following data is based on the product molecular weight 560.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL
10 mM	0.18 mL	0.89 mL	1.78 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Yu Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 2014 PMID: 24775917

Product Documents for DY 268