E 7820

Key Product Details

Product Description

E 7820 is a α₂ integrin inhibitor. Inhibits angiogenesis in vitro (IC₅₀ = 0.11 - 0.25 μM). Also inhibits growth of human colorectal cancer cell lines. Enhances efficacy of erlotinib in a non-small-cell lung cancer xenograft model. Also acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39.

Product Specifications for E 7820

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for E 7820

The following data is based on the product molecular weight 336.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.86 mL	29.73 mL
5 mM	0.59 mL	2.97 mL	5.95 mL
10 mM	0.30 mL	1.49 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ito Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 2014 PMID: 24841832
• Uehara Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat.Chem.Biol. 2017 PMID: 28437394
• Funahashi Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin α2 subunit on endothelium. Cancer Res.

Product Documents for E 7820