(E)-Capsaicin

Tocris Bioscience | Catalog # 0462

TRPV agonist
Tocris Bioscience

Key Product Details

Description

TRPV agonist
View all TRPV Agonists »

Product Description

(E)-Capsaicin is a prototypic vanilloid receptor agonist (pEC50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets.

Product Specifications for (E)-Capsaicin

Molecular Weight

305.42

Formula

C18H27NO3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

CAS Number

404-86-4

PubChem ID

1548943

InChI Key

YKPUWZUDDOIDPM-SOFGYWHQSA-N

SMILES

COC1=C(O)C=CC(CNC(=O)CCCC\C=C\C(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.27 50
Ethanol 15.27 50

Preparing Stock Solutions for (E)-Capsaicin

The following data is based on the product molecular weight 305.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.55 mL 32.74 mL 65.48 mL
2.5 mM 1.31 mL 6.55 mL 13.10 mL
5 mM 0.65 mL 3.27 mL 6.55 mL
25 mM 0.13 mL 0.65 mL 1.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 54 publications citing the usage of this product.

Product Documents for (E)-Capsaicin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (E)-Capsaicin

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for (E)-Capsaicin (2)

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  • enteric nerve study
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: gut
    Verified Customer | Posted 04/26/2023
    Using for trpv1 neuron activation
  • Capsaicin mEPSCs in spinal dorsal horn neuron
    Name: Allen Dickie
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 03/24/2023
    Whole cell patch clamp recording of mEPSCs in spinal dorsal horn interneuron, in ex vivo slice preparation, in response to bath application of capsaicin (2 µM).
    (E)-Capsaicin 0462

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