EB 1089

Name: EB 1089
Brand: Tocris Bioscience
SKU: 3993

Tocris Bioscience | Catalog # 3993

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Citations (21)

Product Documents

Vitamin D receptor (VDR) agonist

Discontinued Product

3993 has been discontinued. View all VDR-like Receptor Agonists products.

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Vitamin D receptor (VDR) agonist

Alternative Names

Seocalcitol

View all VDR-like Receptor Agonists »

Product Description

EB 1089 is a vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

Product Specifications for EB 1089

Molecular Weight

454.68

Formula

C₃₀H₄₆O₃

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

CAS Number

134404-52-7

PubChem ID

5288149

InChI Key

LVLLALCJVJNGQQ-SEODYNFXSA-N

SMILES

C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/C=C/C(CC)(O)CC)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

Hoyer-Hansen Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 2005 PMID: 15905882
Ormerod The calci. analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp.Lung.Rs.
Bhatia EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol.Cancer Ther. 2009 PMID: 19584236
Abdaimi Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer. Cancer Res,
Lu Vitamin D₃ analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Mol.Cancer Ther. 2008 PMID: 18483314

Product Documents for EB 1089

Certificate of Analysis

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Product Specific Notices for EB 1089

For research use only

Citations for EB 1089

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