Echinomycin

Tocris Bioscience | Catalog # 5520

Highly potent and selective HIF-1α inhibitor
Tocris Bioscience

Key Product Details

Description

Highly potent and selective HIF-1α inhibitor

Alternative Names

Quinomycin A
View all HIF Inhibitors »

Product Description

Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.

Product Specifications for Echinomycin

Molecular Weight

1101.26

Formula

C51H64N12O12S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether

CAS Number

512-64-1

PubChem ID

91826096

InChI Key

AUJXLBOHYWTPFV-LDUXBRJQSA-N

SMILES

O=C(N[C@](C(N[C@H](C(N(C)[C@@](C(SC[C@@](N(C)C([C@H](C)NC4=O)=O)([H])C3=O)SC)([H])C(N(C)[C@@H]([C@@H](C)C)C(OC[C@]([H])4NC(C5=CN=C(C=CC=C6)C6=N5)=O)=O)=O)=O)C)=O)([H])COC([C@H]([C@@H](C)C)N3C)=O)C2=NC1=CC=CC=C1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5 5

Preparing Stock Solutions for Echinomycin

The following data is based on the product molecular weight 1101.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 18.16 mL 90.81 mL 181.61 mL
0.25 mM 3.63 mL 18.16 mL 36.32 mL
0.5 mM 1.82 mL 9.08 mL 18.16 mL
2.5 mM 0.36 mL 1.82 mL 3.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Product Documents for Echinomycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Echinomycin

For research use only

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