EGCG

Tocris Bioscience | Catalog # 4524

β-secretase (BACE) inhibitor; inhibits amyloid assembly
Tocris Bioscience

Key Product Details

Description

β-secretase (BACE) inhibitor; inhibits amyloid assembly

Alternative Names

Epigallocatechin gallate
View all Amyloid beta Peptide Inhibitors »

Product Description

EGCG is a β-secretase (BACE1) inhibitor (IC50 = 1.6 μM); inhibits amyloid assembly. Inhibits the formation of amyloid fibrils by proteins such as Aβ, α-synuclein and huntingtin. Reduces Aβ42-induced cell death in three different cell types. Also inhibits glutamate dehydrogenase. Inhibits cell growth and selectively induces apoptosis in A431 and human pancreatic cancer cells. Also a DNMT1 inhibitor.

Product Specifications for EGCG

Molecular Weight

458.37

Formula

C22H18O11

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3,4,5-Trihydroxybenzoic acid (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl ester

CAS Number

989-51-5

PubChem ID

65064

InChI Key

WMBWREPUVVBILR-WIYYLYMNSA-N

SMILES

O=C(C4=CC(O)=C(O)C(O)=C4)O[C@@H]2CC1=C(O)C=C(O)C=C1O[C@@H]2[C@]3=CC(O)=C(O)C(O)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.58 10
DMSO 45.84 100

Preparing Stock Solutions for EGCG

The following data is based on the product molecular weight 458.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.91 mL 21.82 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for EGCG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EGCG

For research use only

Customer Reviews for EGCG (3)

4.3 out of 5
3 Customer Ratings
5 Stars
67%
4 Stars
0%
3 Stars
33%
2 Stars
0%
1 Stars
0%

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  • We got expected effect on cells
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary pancreatic ductal epithelial cells
    Verified Customer | Posted 04/03/2020
    10 μM EGCG
    EGCG 4524
  • Showed no visible purine elusions.
    Name: Scott Scarneo
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/06/2019
    This was used to elute purine binding proteins from cell lysate. The drug gave no visible bands from eluted proteins examined on silver stain.
    EGCG 4524
  • EGCG
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 05/17/2018
    Has expected effect on cells.

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