eIF4A i28

Key Product Details

Product Description

eIF4A i28 is a eukaryotic initiation factor-4A (eIF4A) inhibitor (IC₅₀ = 8.60 μM in an eIF4A ATPase assay). It decreases BJAB Burkitt lymphoma cell viability (EC₅₀ = 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. It acts as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.

Licensing Information

Sold under license from the University of Arizona

Product Specifications for eIF4A i28

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for eIF4A i28

The following data is based on the product molecular weight 416.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.01 mL	60.03 mL	120.07 mL
1 mM	2.40 mL	12.01 mL	24.01 mL
2 mM	1.20 mL	6.00 mL	12.01 mL
10 mM	0.24 mL	1.20 mL	2.40 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zerio Discovery of an eIF4A inhibitor with a novel mechanism of action. J.Med.Chem. 2021 PMID: 34676755

Product Documents for eIF4A i28