EIPA

Tocris Bioscience | Catalog # 3378

Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)
Tocris Bioscience

Key Product Details

Description

Inhibits TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE)

Alternative Names

Ethylisopropyl amiloride
View all TRPP Inhibitors »

Product Description

EIPA is a TRPP3 channel inhibitor (IC50 = 10.5 μM). Inhibits the Na+/H+ exchanger (NHE). Derivative of amiloride (Cat. No. 0890).

Product Specifications for EIPA

Molecular Weight

299.76

Formula

C11H18ClN7O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-Amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide

CAS Number

1154-25-2

PubChem ID

1795

InChI Key

QDERNBXNXJCIQK-UHFFFAOYSA-N

SMILES

ClC1=C(N(C(C)C)CC)N=C(N)C(C(NC(N)=N)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.98 100

Preparing Stock Solutions for EIPA

The following data is based on the product molecular weight 299.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.68 mL 33.36 mL
5 mM 0.67 mL 3.34 mL 6.67 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 50 publications citing the usage of this product.

Product Documents for EIPA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EIPA

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for EIPA (1)

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  • EIPA (Cat. No. 3378)
    Name: Clara Lubeseder-Martellato
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: prmouse pancreatic tumor cell lines
    Verified Customer | Posted 11/12/2021
    EIPA was added to the cells at 25 uM for 48 hours

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