Eletriptan hydrobromide

Key Product Details

Product Description

Orally active, selective 5-HT_1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Eletriptan hydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Eletriptan hydrobromide

The following data is based on the product molecular weight 463.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.79 mL	21.58 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gupta The in vivo pharmacological profile of eletr. (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur.J.Pharmacol. 2000 PMID: 10856450
• Willems Porcine carotid vascular effects of eletr. (UK-116,044): a new 5-HT_1B/1D receptor agonist with anti-migraine activity. Naunyn-Schmied.Arch.Pharmacol.
• Napier Characterisation of the 5-HT receptor binding profile of eletr. and kinetics of [³H]-eletriptan binding at human 5-HT_1B and 5-HT_1D receptors. Eur.J.Pharmacol. 1999 PMID: 10193663

Product Documents for Eletriptan hydrobromide