Ellipticine

Tocris Bioscience | Catalog # 3357

Antitumor and intercalating agent; inhibits DNA topoisomerase II
Tocris Bioscience
Discontinued Product
3357 has been discontinued. View all DNA Topoisomerase Inhibitors products.

Key Product Details

Description

Antitumor and intercalating agent; inhibits DNA topoisomerase II
View all DNA Topoisomerase Inhibitors »

Product Description

Ellipticine is a naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.

Product Specifications for Ellipticine

Molecular Weight

246.31

Formula

C17H14N2

Storage

Store at +4°C

Purity

≥97% (HPLC)

Chemical Name

5,11-Dimethyl-6H-pyrido[4,3-b]carbazole

CAS Number

519-23-3

PubChem ID

3213

InChI Key

CTSPAMFJBXKSOY-UHFFFAOYSA-N

SMILES

CC1=C4C(C=CN=C4)=C(C)C3=C1C2=C(N3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.32 50

Preparing Stock Solutions for Ellipticine

The following data is based on the product molecular weight 246.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.12 mL 40.60 mL 81.20 mL
2.5 mM 1.62 mL 8.12 mL 16.24 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
25 mM 0.16 mL 0.81 mL 1.62 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for Ellipticine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ellipticine

For research use only

Customer Reviews for Ellipticine (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Ellipticine?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • Ellipticine quickly kills melanoma cells in vitro
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/14/2019
    Ellipticine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
    Ellipticine 3357

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All