EM12-SO₂F

Key Product Details

Product Description

EM12-SO₂F is a potent covalent Cereblon (CRBN) inhibitor (IC₅₀ = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO₂F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

Product Specifications for EM12-SO₂F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for EM12-SO₂F

The following data is based on the product molecular weight 326.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.06 mL	15.32 mL	30.65 mL
5 mM	0.61 mL	3.06 mL	6.13 mL
10 mM	0.31 mL	1.53 mL	3.06 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cruite Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 2022 PMID: 36128501

Product Documents for EM12-SO₂F