EMI 48

Tocris Bioscience | Catalog # 7424

Inhibitor of EGFR mutants
Tocris Bioscience
Discontinued Product
7424 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description

Inhibitor of EGFR mutants
View all EGF Receptor Inhibitors »

Product Description

EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.

Product Specifications for EMI 48

Molecular Weight

348.40

Formula

C21H20N2O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one

CAS Number

34564-13-1

PubChem ID

15538560

InChI Key

PTAGJQADNFQMGR-UHFFFAOYSA-N

SMILES

CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.97 20 with gentle warming

Preparing Stock Solutions for EMI 48

The following data is based on the product molecular weight 348.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.35 mL 71.76 mL 143.51 mL
1 mM 2.87 mL 14.35 mL 28.70 mL
2 mM 1.44 mL 7.18 mL 14.35 mL
10 mM 0.29 mL 1.44 mL 2.87 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for EMI 48

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for EMI 48

For research use only

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