Endomorphin-1

Name: Endomorphin-1
Brand: Tocris Bioscience
SKU: 1055

Tocris Bioscience | Catalog # 1055

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Citations (16)

Product Documents

Potent and selective μ agonist

Discontinued Product

1055 has been discontinued. View all mu Opioid Receptor Agonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective μ agonist

View all mu Opioid Receptor Agonists »

Product Description

Endomorphin-1 is a endogenous peptide with an exceptionally high affinity (K_i = 360 pM) and selectivity for μ opioid receptors (4000- and 15000-fold preference over δ and κ respectively).

Product Specifications for Endomorphin-1

Molecular Weight

610.67

Formula

C₃₄H₃₈N₆O₅

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

189388-22-5

PubChem ID

5311080

InChI Key

ZEXLJFNSKAHNFH-SYKYGTKKSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.6mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

Zadina A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997 PMID: 9087409
Harrison Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes. Peptides 1998 PMID: 9622031
Kakizawa Parallel stimulations of in vitro and in situ [³⁵S]GTPγS binding by endomorphin 1 and DAMGO in mouse brains. Peptides 1998 PMID: 9622032
Goldberg Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9694962

Product Documents for Endomorphin-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Endomorphin-1

For research use only

Citations for Endomorphin-1

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