Epiblastin A

Key Product Details

Product Description

Epiblastin A is a CK1 inhibitor (IC₅₀ values are 0.8, 3.7 and 3.8 μM for CK1δ, CK1ε and CK1α). Converts late-stage epiblast stem cells into germline-competent embryonic SC-like cells. Promotes activation and maintenance of the pluripotency network. Promotes ESC self-renewal at a concentration of 2 μM.

Product Specifications for Epiblastin A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Epiblastin A

The following data is based on the product molecular weight 287.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	17.38 mL	86.89 mL	173.79 mL
1 mM	3.48 mL	17.38 mL	34.76 mL
2 mM	1.74 mL	8.69 mL	17.38 mL
10 mM	0.35 mL	1.74 mL	3.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Ursu Epiblastin A induces reprogramming of epiblast stem cells Into embryonic stem cells by inhibition of casein kinase 1. Cell Chem.Bio. 2016 PMID: 27049670
• Illich Distinct signaling requirements for the establishment of ESC pluripotency in late-stage EpiSCs. Cell Rep. 2016 PMID: 27149845

Product Documents for Epiblastin A