Eplerenone

Key Product Details

Product Description

Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC₅₀ = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC₅₀ > 10 μM). Orally active antihypertensive in vivo.

Product Specifications for Eplerenone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Eplerenone

The following data is based on the product molecular weight 414.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.13 mL	120.63 mL	241.25 mL
0.5 mM	4.83 mL	24.13 mL	48.25 mL
1 mM	2.41 mL	12.06 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• McMahon and Cunningham Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 2001 PMID: 11714095
• De Gasparo Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 1987 PMID: 2949071

Product Documents for Eplerenone