Erastin

Key Product Details

Product Description

Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Product Specifications for Erastin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Erastin

The following data is based on the product molecular weight 547.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.70 mL	91.40 mL
1 mM	1.83 mL	9.14 mL	18.28 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

• Yagoda RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 2007 PMID: 17568748
• Dixon Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012 PMID: 22632970
• Dolma Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003 PMID: 12676586

Product Documents for Erastin