ESI 05

Key Product Details

Product Description

ESI 05 is an EPAC2 inhibitor. Inhibits cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC₅₀ = 0.4 μM).

Product Specifications for ESI 05

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ESI 05

The following data is based on the product molecular weight 274.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.64 mL	18.22 mL	36.45 mL
5 mM	0.73 mL	3.64 mL	7.29 mL
10 mM	0.36 mL	1.82 mL	3.64 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Tsalkova Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA. 2012 PMID: 23091014

Product Documents for ESI 05