ET 18-OCH₃

Key Product Details

Product Description

ET 18-OCH₃ is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC₅₀ = 9.6 μM in fibroblasts and adenocarcinoma cells). ET 18-OCH₃ acts as an agonist at platelet-activating factor (PAF) receptors. ET 18-OCH₃ is an antitumor lipid that selectively induces apoptosis in tumor cells, sparing normal cells, and activates the intracellular Fas/CD95 death receptor. ETH 18-OCH₃ also triggers eryptosis and interacts with mitochondrial membranes to increase mitochondrial membrane permeability, leading to dysfunction and apoptosis. Racemic mixture.

Product Specifications for ET 18-OCH₃

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ET 18-OCH₃

The following data is based on the product molecular weight 523.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.55 mL	47.73 mL	95.47 mL
1 mM	1.91 mL	9.55 mL	19.09 mL
2 mM	0.95 mL	4.77 mL	9.55 mL
10 mM	0.19 mL	0.95 mL	1.91 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Wong Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 2007 PMID: 17509155
• Shimizu Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 2007 PMID: 17628524
• Aoki A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 1995 PMID: 7594622
• Powis Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 1992 PMID: 1316230
• Briglia Edelfosine induced suicidal death of human erythrocytes. Cell.Physiol.Biochem. 2015 PMID: 26618532
• Mollinedo ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr.Med.Chem. 2004 PMID: 15579006

Product Documents for ET 18-OCH₃