Ethyl LipotF

Key Product Details

Product Description

Ethyl LipotF is a selective FTO inhibitor (IC₅₀ = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N⁶-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner.

Product Specifications for Ethyl LipotF

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ethyl LipotF

The following data is based on the product molecular weight 353.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cheong A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N⁶-methyladenosine demethylase activity in cells. Chem.Sci. 2018 PMID: 30288236
• Toh A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N⁶-methyladenosine demethylase FTO. Chem.Sci. 2015 PMID: 28553460

Product Documents for Ethyl LipotF