Etoposide

Tocris Bioscience | Catalog # 1226

Topoisomerase II inhibitor
Tocris Bioscience

Key Product Details

Description

Topoisomerase II inhibitor
View all DNA Topoisomerase Inhibitors »

Product Description

Etoposide is a DNA topoisomerase II inhibitor (IC50 = 59.2 μM). Anticancer. Also enhances adeno-associated virus (AAV) transduction of HeLa cells.

Product Specifications for Etoposide

Molecular Weight

588.56

Formula

C29H32O13

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

[5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one

CAS Number

33419-42-0

PubChem ID

36462

InChI Key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

SMILES

OC(C(OC)=C3)=C(OC)C=[C@@]3[C@@H]2C1=CC6=C(OCO6)C=C1[C@@H](O[C@]4([H])O[C@@](CO[C@@H](C)O7)([H])[C@]7([H])[C@H](O)[C@H]4O)[C@@H]5[C@@H]2[C@](OC5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.86 100

Preparing Stock Solutions for Etoposide

The following data is based on the product molecular weight 588.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.70 mL 8.50 mL 16.99 mL
5 mM 0.34 mL 1.70 mL 3.40 mL
10 mM 0.17 mL 0.85 mL 1.70 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Calculators

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Product Documents for Etoposide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Etoposide

For research use only

⚠ WARNING: This product can expose you to chemicals including Etoposide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Customer Reviews for Etoposide (2)

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  • Etoposide for inducing DSBs
    Name: Xiaoyu Zhang
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: neuronal cells
    Verified Customer | Posted 06/23/2023
    Neurons were treated with 1 uM Etoposide to induce DNA double-strand breaks (DSBs), followed by gH2ax staining to detect DSBs.
    Etoposide 1226
  • Etoposide inhibits growth of melanoma cell line at micromolar concentrations
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: SK-MEL-28
    Verified Customer | Posted 02/07/2019
    Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).
    Etoposide 1226

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