Fatostatin A

Key Product Details

Product Description

Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC₅₀ = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.

Product Specifications for Fatostatin A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Fatostatin A

The following data is based on the product molecular weight 375.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.32 mL	66.61 mL	133.22 mL
1 mM	2.66 mL	13.32 mL	26.64 mL
2 mM	1.33 mL	6.66 mL	13.32 mL
10 mM	0.27 mL	1.33 mL	2.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Choi Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 2003 PMID: 12496288
• Kamisuki A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 2009 PMID: 19716478

Product Documents for Fatostatin A