Febuxostat

Key Product Details

Product Description

Febuxostat is a non-purine inhibitor of xanthine oxidase (K_i = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

Product Specifications for Febuxostat

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Febuxostat

The following data is based on the product molecular weight 316.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.21 mL	21.07 mL	42.14 mL
3.75 mM	0.84 mL	4.21 mL	8.43 mL
7.5 mM	0.42 mL	2.11 mL	4.21 mL
37.5 mM	0.08 mL	0.42 mL	0.84 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Xu Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 2008 PMID: 18995179
• Okamoto An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 2003 PMID: 12421831
• Osada Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 1993 PMID: 8243554

Product Documents for Febuxostat