FGIN-1-27

Key Product Details

Product Description

Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC₅₀ = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation.

Product Specifications for FGIN-1-27

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FGIN-1-27

The following data is based on the product molecular weight 436.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.45 mL	22.90 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Kozikowski Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABA_A receptor modulation. Angew.Chem.Int.Ed.
• Romeo 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 1992 PMID: 1326631

Product Documents for FGIN-1-27