FIPI

Tocris Bioscience | Catalog # 3600

Phospholipase D inhibitor
Tocris Bioscience
Discontinued Product
3600 has been discontinued. View all Phospholipase Inhibitors products.

Key Product Details

Description

Phospholipase D inhibitor
View all Phospholipase Inhibitors »

Product Description

FIPI is a potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.

Product Specifications for FIPI

Molecular Weight

457.93

Formula

C23H24FN5O2.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride

CAS Number

1781834-93-2

PubChem ID

90488864

InChI Key

BNMQCDOCYPGJJD-UHFFFAOYSA-N

SMILES

O=C(N2)N(C3CCN(CCNC(C4=CC5=C(C=CC(F)=C5)N4)=O)CC3)C1=C2C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.9 50

Preparing Stock Solutions for FIPI

The following data is based on the product molecular weight 457.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.37 mL 21.84 mL 43.67 mL
2.5 mM 0.87 mL 4.37 mL 8.73 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for FIPI

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FIPI

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Customer Reviews for FIPI (2)

5 out of 5
2 Customer Ratings
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4 Stars
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  • great product
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampal neuron
    Verified Customer | Posted 03/26/2020
    100 μM treat 45min
    FIPI 3600
  • used this drug as an inhibitor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: macrophages
    Verified Customer | Posted 10/05/2017
    Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
    FIPI 3600

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