FITM

Key Product Details

Product Description

FITM is a potent and selective negative allosteric modulator of mGlu₁ receptors (IC₅₀ = 5.1 nM). Displays >1300-fold selectivity for mGlu₁ over other metabotropic glutamate receptors (IC₅₀ values are 7 μM and >10 μM for mGlu₅ and mGlu₂ or mGlu₈, respectively). Antagonizes methamphetamine-induced locomotion in mice.

Product Specifications for FITM

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FITM

The following data is based on the product molecular weight 371.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.35 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wu Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science. 2014 PMID: 24603153
• Satoh Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist. Bioorg.Med.Chem.Lett. 2009 PMID: 19674894

Product Documents for FITM