Fludarabine

Tocris Bioscience | Catalog # 3495

Purine analog; inhibits DNA synthesis
Tocris Bioscience

Key Product Details

Description

Purine analog; inhibits DNA synthesis
View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Fludarabine is a purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo.

Product Specifications for Fludarabine

Molecular Weight

285.23

Formula

C10H12FN5O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

CAS Number

21679-14-1

PubChem ID

657237

InChI Key

HBUBKKRHXORPQB-FJFJXFQQSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N3C2=NC(F)=NC(N)=C2N=C3)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.52 100

Preparing Stock Solutions for Fludarabine

The following data is based on the product molecular weight 285.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.70 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for Fludarabine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Fludarabine

For research use only

Customer Reviews for Fludarabine (1)

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  • STAT1 inhibitor in IFN beta signaling
    Name: Richa Rani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Hepatic stellate cells and hepatocytes
    Verified Customer | Posted 01/04/2018
    I used it to check its effect on drug stimulated hepatic stellate cell and its signaling.
    Fludarabine 3495

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