FM19G11

Tocris Bioscience | Catalog # 6653

HIF α-subunit inhibitor
Tocris Bioscience

Key Product Details

Description

HIF α-subunit inhibitor
View all HIF Inhibitors »

Product Description

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Product Specifications for FM19G11

Molecular Weight

463.40

Formula

C23H17N3O8

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate

CAS Number

329932-55-0

PubChem ID

1730746

InChI Key

XVUOIWIIQVGWAJ-UHFFFAOYSA-N

SMILES

CC1=CC=C(C(COC(C2=CC=CC(NC(C3=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C3)=O)=C2)=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.34 100

Preparing Stock Solutions for FM19G11

The following data is based on the product molecular weight 463.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for FM19G11

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for FM19G11

For research use only

Customer Reviews for FM19G11 (1)

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  • good product, satisfied
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hepg2, Huh7
    Verified Customer | Posted 02/17/2020
    Used this in 100nM for 24 hours in cultured cells and inhibited HIF1 level in the cells (checked by western blotting)
    FM19G11 6653

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