FMK 9a

Key Product Details

Product Description

FMK 9a is a potent ATG4B/autophagin-1 inhibitor (IC₅₀ values are 73 nM and 80 nM in cell-based LRA and TR-FRET assays, respectively). Also inhibits calpain and cathepsin B (IC₅₀ values are 96 nM and 200 nM, respectively).

Product Specifications for FMK 9a

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FMK 9a

The following data is based on the product molecular weight 392.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Qiu Discovery of fluoromethylketone-based peptidomimetics as covalent ATG4B (autophagin-1) inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27563406

Product Documents for FMK 9a