FPL 64176

Key Product Details

Product Description

FPL 64176 is a potent activator of L-type Ca²⁺ channels (EC₅₀ = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.

Product Specifications for FPL 64176

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FPL 64176

The following data is based on the product molecular weight 347.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.76 mL	28.78 mL	57.57 mL
2.5 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.58 mL	2.88 mL	5.76 mL
25 mM	0.12 mL	0.58 mL	1.15 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

• Rampe Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca⁺⁺ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 1993 PMID: 7685384
• Zheng Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca²⁺ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 1991 PMID: 1719369
• Baxter Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J.Med.Chem. 1993 PMID: 7692047

Product Documents for FPL 64176