FPR A14
Discontinued Product
Chemical Name: 1,3-Benzodioxolane-5-carboxylic acid 4'-benzyloxy-3'-methoxybenzylidene hydrazide
Purity: ≥99%
Biological Activity
Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Induces dose-dependent differentiation of mouse neuroblastoma N2a cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput screening for small molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists.
Schepetkin et al.
Mol.Pharmacol., 2007;71:1061 -
The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.
Cussell et al.
PLoS One, 2019;14:e0217815
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Citations for FPR A14
The citations listed below are publications that use Tocris products. Selected citations for FPR A14 include:
2 Citations: Showing 1 - 2
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The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.
Authors: Cussell Et al.
PLoS One. 2019;14:e0217815
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Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish.
Authors: Yan Et al.
J Hepatol 2015;63:420
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