FRAX 597

Key Product Details

Product Description

FRAX 597 is a potent group I PAK inhibitor (IC₅₀ values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). FRAX 597 exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC₅₀ >10 μM for PAK4). FRAX 597 inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.

Product Specifications for FRAX 597

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for FRAX 597

The following data is based on the product molecular weight 558.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.96 mL	44.79 mL	89.59 mL
1 mM	1.79 mL	8.96 mL	17.92 mL
2 mM	0.90 mL	4.48 mL	8.96 mL
10 mM	0.18 mL	0.90 mL	1.79 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Yeo FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcit. BMC Cancer 2016 PMID: 26774265
• Licciulli FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J.Biol.Chem. 2013 PMID: 23960073

Product Documents for FRAX 597